Ke kū nei ka ʻoihana kemika honua i nā pilikia hoʻokele wela i manaʻo ʻole ʻia i ka wā e hoʻoikaika ai nā mea hana no ka ʻoi aku ka maikaʻi, nā kūlana palekana koʻikoʻi, a me ka mālama ʻana i ke kaiapuni. Hana nā kaʻina hana kemika ma nā pae mahana koʻikoʻi mai -110°C mau noi cryogenic a hiki i 200°C mau hopena wela kiʻekiʻe, e koi ana i nā hopena hoʻoili wela pololei e hiki ke lawelawe i nā kaiapuni corrosive, nā hopena wai-sensitive, a me nā mea weliweli. Hoʻopau nā kaʻina hana cryogenic ikaika i ka ikehu i ka ikehu wela nui, ʻoiai ʻo ka pale ʻana i ka corrosion kūpono ʻole e hōʻemi i ke ola o nā lako ma 50%. ʻO kahi ʻōnaehana coolant maʻamau e pili ana i kahi pahu buffer: hoʻopuni ka pamu mua i ka coolant ma waena o ka pahu buffer a me ka ʻāpana refrigeration e hana a mālama i ka coolant haʻahaʻa haʻahaʻa, ʻoiai ke kaʻapuni ka pamu lua ma waena o ka reactor a me ka pahu buffer, e hōʻoiaʻiʻo ana i nā hopena paʻa i nā reactors kemika maikaʻi. Hoʻoponopono nā wai hoʻoili wela kūikawā a Glacier Coolant i kēia mau pilikia me nā pae mahana ākea, ke kūpaʻa kemika, nā ʻano hana wai-ʻole no nā kaʻina hana anhydrous, a me ka pale ʻana i ka corrosion piha ma waena o ke kila kalapona, ke kila kila, a me nā ʻōnaehana keleawe.